Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens

Abstract : To evaluate the effect of cellulosic polymers (CEL) and curcumin (CUR) on aflatoxin B1 (AFB1) toxic effects on performance, and the biochemical and immunological parameters in broiler chickens, 150 one-day-old male broiler chicks were randomly allocated into five groups with three replicates of 10 chickens per pen: Negative Control (feed); AFB1 (feed + 2 ppm AFB1); CUR (feed + 2 ppm AFB1 + Curcumin 0.2%); CEL (feed + 2 ppm AFB1 + 0.3% Cellulosic polymers); and, CEL + CUR (feed + 2 ppm AFB1 + 0.3% Cellulose polymers + 0.2% Curcumin). Every week, body weight, body weight gain, feed intake, and feed conversion ratio were calculated. On day 21, liver, spleen, bursa of Fabricius, and intestine from five broilers per replicate per group were removed to obtain relative organ weight. Histopathological changes in liver, several biochemical biomarkers, antibody titers, and muscle and skin pigmentation were also recorded. Dietary addition of 0.3% CEL and 0.2% CUR separately significantly diminished some of the toxic effects resulting from AFB1 on performance parameters, relative organs weight, histopathology, immune response, and serum biochemical variables (P < 0.05); however, the combination of CUR and CEL showed a better-integrated approach for the management of poultry health problems that are related with the consumption of AFB1, since they have different mechanisms of action with different positive effects on the responses of broiler chickens.
Complete list of metadatas

Cited literature [92 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02320084
Contributor : Stéphanie Dutilloy <>
Submitted on : Friday, October 18, 2019 - 2:33:24 PM
Last modification on : Saturday, October 19, 2019 - 1:21:37 AM

File

SOLIS-CRUZ_Toxins_2019.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Bruno Solis-Cruz, Daniel Hernandez-Patlan, Victor Petrone, Karine Pontin, Juan Latorre, et al.. Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens. Toxins, MDPI, 2019, 11 (2), pp.121. ⟨10.3390/toxins11020121⟩. ⟨hal-02320084⟩

Share

Metrics

Record views

38

Files downloads

24