 |
 |
|
|
| HAL : hal-00582682, version 1 |
| Fiche détaillée |  Récupérer au format |
 |
| MODGRAPH - Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM) (2009) 42-46 |
|
|
|
|
| Reconstruction of gene regulation networks from microarray data by Bayesian networks |
|
|
Hoai-Tuong Nguyen 1Gérard Ramstein 1 |
|
|
| (09/06/2009) |
|
|
|
| In this work, we reconstruct the gene regulation networks from the microarray experiments data by Bayesian networks approach. We use the evolutionary algorithm for the search-and-score based structure learning methods. The learned network is tested by the hypothesis testing with two populations of patient data, one with treatment (drugs), other without treatment. The answer of question "How does the treatment influence to gene regulation?" is expected. |
|
|
|
|
|
|
|
|
|
|
|
| 1 : | Laboratoire d'Informatique de Nantes Atlantique (LINA) |
|
|
|
CNRS : UMR6241 – Université de Nantes – Ecole des Mines de Nantes |
|
|
| 2 : | Centre de Recherche en Cancérologie Nantes - Angers (CRCNA) |
|
|
|
INSERM : U892 – Université de Nantes |
|
|
|
|
|
|
|
|
|
| LINA CNRS 6241; CRCNA INSERM 892 |
|
|
|
|
| Domaine | : | Informatique/Bio-informatique Sciences du Vivant/Bio-Informatique, Biologie Systémique |
|
|
| Gene expression – microarray – gene regulation networks – Bayesian networks – genetic algorithm – estimation of distribution algorithm. |
|
|
|
| Liste des fichiers attachés à ce document : | ||||||||||
|
||||||||||
|
|
|
| hal-00582682, version 1 | |
| http://hal.univ-nantes.fr/hal-00582682 | |
| oai:hal.univ-nantes.fr:hal-00582682 | |
| Contributeur : Hoai-Tuong Nguyen | |
| Soumis le : Dimanche 3 Avril 2011, 17:42:26 | |
| Dernière modification le : Vendredi 16 Décembre 2011, 23:47:48 | |
