MeDUSA: a sage-based tool for computing the stoichiometric capacitance of a metabolic network

Marko Budinich 1, * Damien Eveillard 2 Jérémie Bourdon 2 Abdelhalim Larhlimi 3, *
* Corresponding author
1 combi
CMM - Centre de Modélisation Mathématique / Centro de Modelamiento Matemático, LINA - Laboratoire d'Informatique de Nantes Atlantique
3 Combi
LINA - Laboratoire d'Informatique de Nantes Atlantique
Abstract : Optimization-based analysis of metabolic networks have been used to design metabolic engineering strategies aiming at enhancing the production of a target of interest. Here, we present MeDUSA, a comprehensive tool for the calculation of a stoichiometric capacitance allowing for increasing the maximum production of a given product. MeDUSA provides an extensive sage-based package which, given a metabolic network and an objective function, (i) computes a stoichiometric capacitance and (ii) investigates the effect of adding the calculated stoichiometric capacitance.
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Submitted on : Friday, June 28, 2013 - 10:02:18 AM
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Marko Budinich, Damien Eveillard, Jérémie Bourdon, Abdelhalim Larhlimi. MeDUSA: a sage-based tool for computing the stoichiometric capacitance of a metabolic network. 2013. ⟨hal-00839321⟩

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