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A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: Syringe-foaming using a viscous hydrophilic polymeric solution

Abstract : In this study, we propose a simple and effective strategy to prepare injectable macroprous calcium phosphate cements (CPCs) by syringe-foaming via hydrophilic viscous polymeric solution, such as using silanized-hydroxypropyl methylcellulose (Si-HPMC) as a foaming agent. The Si-HPMC foamed CPCs demonstrate excellent handling properties such as injectability and cohesion. After setting the foamed CPCs possess hierarchical macropores and their mechanical properties (Young's modulus and compressive strength) are comparable to those of cancellous bone. Moreover, a preliminary in vivo study in the distal femoral sites of rabbits was conducted to evaluate the biofunctionality of this injectable macroporous CPC. The evidence of newly formed bone in the deep zone of implantation site indicates the feasibility and effectivity of this foaming strategy. Finally, the optimizing hydrogel formulation and alternative viscous hydrophilic polymers have been considered.
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https://hal.archives-ouvertes.fr/hal-01723572
Contributor : Richard Baschera <>
Submitted on : Wednesday, March 3, 2021 - 9:30:05 AM
Last modification on : Thursday, March 4, 2021 - 11:49:17 AM

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Jingtao Zhang, Weizhen Liu, Olivier Gauthier, Sophie Sourice, Paul Pilet, et al.. A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: Syringe-foaming using a viscous hydrophilic polymeric solution. Acta Biomaterialia, Elsevier, 2016, 31, pp.326-338. ⟨10.1016/j.actbio.2015.11.055⟩. ⟨hal-01723572⟩

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