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Evidence for a vasomotor cyclo-oxygenase dependent mechanism of sensitization at the cutaneous level.

Abstract : Aims - Current-induced vasodilation (CIV) is an axon-reflex response observed during monopolar current application such as iontophoresis. Cyclo-oxygenase derivates (COD) participate in CIV and act as sensitizing agents at the anodal level. Mechanisms involved during cathodal current application (CCA) are partially unknown. In a randomized double-blind crossover trial, we tested in 16 healthy subjects (i) the influence of the inter-stimulation interval (I-I) by comparing CIV following all-at-once 10 s CCA against 2 × 5 s CCA with intervals ranging from15 s-16 min and (ii) the participation of COD in CIV using 1 g aspirin or placebo intake. Methods - Measurements were repeated 2 h and 14 days after treatment. Laser Doppler flowmetry assessed cutaneous blood flow, reported in multiples of baseline. Results - Before treatment, peak vasodilation 10 min after the last current application (CVCstim2 ) increased compared with baseline whatever the I-I. Increase in CVCstim2 from baseline was greater for the 4 min (9.4 (5.3, 10.9) times; median (1(st) percentile, 3(rd) percentile)) and higher I-Is compared with all-at-once delivery (3.0 (2.1, 4.3) times, P < 0.05). The response was similar after placebo but aspirin abolished this vasodilation (increase by 1.2 (1.1, 1.3) times for all-at-once delivery and by 1.5 (1.3, 1.7) ± 0.3 times for 4 min interval, 2 h after aspirin intake) that recovered after 14 days. Conclusions - This confirms the participation of COD in CIV with CCA and their sensitizing action. This model can represent an attractive way to study the axon-reflex and sensitizing function of COD in humans.
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Submitted on : Tuesday, March 24, 2020 - 3:49:30 PM
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Gil Mahe, Pierre Abraham, A. Humeau-Heurtier, Lydie Gascoin, G. Leftheriotis, et al.. Evidence for a vasomotor cyclo-oxygenase dependent mechanism of sensitization at the cutaneous level.. British Journal of Clinical Pharmacology, Wiley, 2015, 80 (2), pp.185-192. ⟨10.1111/bcp.12623⟩. ⟨hal-02369574⟩

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