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Psychiatric disorders secondary to neurometabolicdisorders

Abstract : Some diseases secondary to inborn errors of metabolism are associated with psychiatricdisorders or minor neurological symptoms. The existence of some cases with exclusivelypsychiatric symptoms represents a diagnostic and therapeutic challenge. The aim of thisarticle is to describe seven treatable neurometabolic disorders that should be taken intoaccount in the psychiatric consultation as they manifest with psychiatric symptoms thatmask the organic origin of the disorder. Homocysteine metabolism and urea cycle disor-ders, Wilson’s disease, Niemann-Pick disease Type C, acute porphyria and cerebrotendinousxanthomatosis are described. Following an analysis of the literature, a list of psychiatricsymptoms associated with these disorders are proposed, ranging from insidious changes inaffective state and thought to atypical symptoms such as visual hallucinations, as well asparadoxical effects of antipsychotics or behavioural disorders in children and adolescentsassociated with loss of autonomy. The most frequently associated neurological signs, suchas alterations in the state of consciousness, motor behaviour and balance disorders, catato-nia or progressive cognitive deficit are also listed. Emphasis is placed on the importance ofconsidering resistance to antipsychotic treatment as a warning sign to suspect organicity,as well as the significant improvement in psychiatric impairment when effective and earlytreatment is established.
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http://hal.univ-nantes.fr/hal-03320553
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Submitted on : Monday, August 16, 2021 - 10:18:58 AM
Last modification on : Tuesday, August 17, 2021 - 3:23:28 AM

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Paula Herrera, Alberto Vélez van Meerbeke, Olivier Bonnot. Psychiatric disorders secondary to neurometabolicdisorders. Revista Colombiana de Psiquiatría, Asociación Colombiana de Psiquiatría, 2018, 47 (4), pp.244-251. ⟨10.1016/j.rcp.2017.05.004⟩. ⟨hal-03320553⟩

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